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ılımlı ve belli belirsiz böbrek yetmezliği olanlarda yetişkinler dâhilin referans edilen doz rejimi uygulanır.Ağır böbrek yetmezliği olan (kreatinin klirensi 150 mM)ün zebun bir inhibitörüdür. Referans edilen dozların peşi sıra sildenafilin şahika plazma konsantrasyonu takribî 1 mM oldu